Nucleic Acid Synthesis
Apexbio Technology LLC EZLink Sulfo-NHS-SS-Biotin Kit, 10 reactions
The EZLink Sulfo-NHS-SS-Biotin Kit contains reagents sufficient for 10 biotin labeling reactions. It is a water-soluble biotin reagent for labeling protein, antibody or other molecules with amidogen (NH2-). The biotin in the kit is sufficient and has been activated for direct use. The whole procedure is simple and quick. Other sizes are available. Please inqury us for quote.
Cayman Chemical ANTIBODY SGC3027 1mg
A prodrug form of the PRMT7 inhibitor SGC8158; converted by intracellular reductases to SGC8158; inhibits methylation of Hsp70 in vitro (IC50 = 2.4 µM)
Medchemexpress LLC Pseudouridine (standard) | 1445-07-4 | 100.0% | 244.20 | 10 MG
Pseudouridine (Standard) is the analytical standard of Pseudouridine, intended for research and analytical applications. It is the most abundant modified nucleoside in non-coding RNAs, and in rRNA and tRNA, it helps fine-tune and stabilize regional structure, maintaining their functions in mRNA decoding, ribosome assembly, processing and translation.
- Used as an analytical standard and reference standard.
- Commonly used in qualitative, quantitative, and methodological research experiments.
- Applicable in HPLC, GC, and MS.
Cayman Chemical Indole-3-thIo CarboxamIde 1g
A synthetic intermediate useful for pharmaceutical synthesis
Medchemexpress LLC 2'-O-Methyluridine | 2140-76-3 | 99.8% | 258.23 | 5 G
2'-O-Methyluridine is a modified nucleoside that can be found in *T. thermophile* tRNA. Its level in serum is decreased in patients with breast cancer. It can be incorporated into siRNA targeting the gene encoding apolipoprotein B, which decreases ApoB protein levels in HepG2 and prevents IFN-α production in isolated human PBMCs.
- Found in *T. thermophile* tRNA
- Decreased serum levels in breast cancer patients
- Can be incorporated into siRNA
- Decreases ApoB protein levels in HepG2
- Prevents IFN-α production in isolated human PBMCs
Medchemexpress LLC Nucleoside-Analog-1 | 876707-99-2 | >95.0% | C9H9N5O5 | 50 MG
Nucleoside-Analog-1 is a click chemistry reagent containing an azide group. It can participate in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups, and in strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
- Click chemistry reagent containing an azide group.
- Participates in copper-catalyzed azide-alkyne cycloaddition (CuAAc) reactions with molecules containing alkyne groups.
- Undergoes strain-promoted alkyne-azide cycloaddition (SPAAC) reactions with molecules containing DBCO or BCN groups.
Biotium BrdU (5-Bromo-2'-Deoxyuridine)
BrdU (5-Bromo-2′-deoxyuridine) can be incorporated into DNA during cell division and subsequently detected by a BrdU antibody. The probe is useful for studying cell-cycle kinetics. Properties: White solid soluble in DMSO; Store at -20⁰C; C9H11BrN2O5; MW: 307.10; [59-14-3].
Medchemexpress LLC Pseudouridine | 1445-07-4 | MFCD00038458 | 99.9% | 244.20 | 5 MG
Pseudouridine is an isomer of uridine and the most abundant modified nucleoside in non-coding RNA. It fine-tunes and stabilizes regional structures in rRNA and tRNA, maintaining their functions in mRNA decoding, ribosome assembly, processing, and translation. Pseudouridine-modified tRNA fragments can inhibit aberrant protein synthesis and hold promise for research on myelodysplastic syndrome (MDS)-related leukemia.
- Most abundant modified nucleoside in non-coding RNA
- Fine-tunes and stabilizes regional structures in rRNA and tRNA
- Maintains functions in mRNA decoding, ribosome assembly, processing, and translation
- Inhibits aberrant protein synthesis
- Forms additional hydrogen bonds, stabilizing RNA and improving base stacking
- Found in all three phylogenetic domains of life
Cayman Chemical Pseudouridine 5mg
The C-5 glycoside isomer of uridine; formed when uridine in RNA undergoes site-specific isomerization by a pseudouridine synthase enzyme; found in tRNAs from bacteria, archaea, and eukaryotes; reduces the number of X-ray-induced chromosomal aberrations in human lymphocytes isolated from whole blood in a dose-dependent manner
Medchemexpress LLC 6-Methyluridine | 16710-13-7 | C10H14N2O6 | 25 MG
6-Methyluridine is a uridine analogue. Uridine has potential antiepileptic effects, and its analogs can be used to study anticonvulsant and anxiolytic activities, as well as to develop new antihypertensive agents.
- Uridine analogue
- Potential antiepileptic effects
- Used to study anticonvulsant and anxiolytic activities
- Used to develop new antihypertensive agents
Sigma Aldrich Fine Chemicals Biosciences Thymidine | 50-89-5 | MFCD00006537 | 1g
Thymidine | Purity: 99% | Mol Wt: 242.23 | 50-89-5 | MFCD00006537 | 1g
Apexbio Technology LLC 6-Thio-dG 789-61-7 5mg
6-Thio-2 -deoxyguanosine (6-Thio-dG CAS 789-61-7) is a nucleoside analogue that functions as a telomerase-mediated telomere targeting agent In telomerase-positive cancer cells 6-Thio-dG is incorporated into telomeric DNA inducing rapid telomere dysfunction independent of direct telomerase inhibition which leads to growth arrest and cell death In vitro cancer cell lines exhibit IC50 values ranging from 0 7 to 2 9 M indicating high sensitivity to the compound Normal cells with telomerase-silent status show minimal morphological effects upon 6-Thio-dG exposure In vivo 6-Thio-dG administration inhibits tumor growth and reduces proliferation markers in xenograft models The compound is valuable for investigating telomere biology and as a tool to evaluate telomerase-dependent therapeutic strategies in cancer research
ABclonal Technology 2-O-methylcytidine/ Cm
RNA methylation plays a significant regulatory role in various of physiological activities 2 -O-methylcytidine (Cm) is one of the representative 2 -O-methylation and base-methylation modified epigenetic marks of RNA 2 -O-Methylcytidine is derivative of the nucleoside residue cytidine with a methyl group attached to the 2 -oxygen position 2 -O-methylcytidine was found to be related to various diseases including cancer and it might have great potential to be novel biomarkers for detection of breast cancer in the early stage In addition 2 -O-methylcytidine showed as an inhibitor of RNA polymerase from the hepatitis C virus (HCV) And 2 -O-methylcytidine was involved in plant stress responses
Medchemexpress LLC HY-15910 100mg Medchemexpress, 5-BrdU CAS:59-14-3 Purity:>98%
Medchemexpress, HY-15910 100mg 5-BrdU CAS:59-14-3 5-BrdU (BrdU) is a nucleoside analog that competes with thymidine for incorporation into DNA. 5-BrdU is commonly used in the detection of proliferating cells. Purity:>98% Medchemexpress has over 10000 novel life-science reagents, reference compounds, APIs and natural compounds for laboratory and scientific use. Other quantity can also be offered.